This study explores how healthcare professionals' attitudes and knowledge impact organ utilization in Brazil and proposes practical managerial and operational recommendations to improve transplantation efficiency. Based on an international expert panel composed of 13 professionals from Brazil, Argentina, Spain, and the United States, the research applies the People, Process, and Technology (PPT) model to categorize and analyze findings. The panel identified critical barriers to organ utilization, especially related to behavioral and knowledge-based factors among professionals involved in the organ donation-transplantation (ODT) process. Emphasis was placed on the need for specialized training, data-driven decision-making, performance monitoring, and improved communication between transplant teams. The results indicate that interventions focused on human resources and organizational processes—rather than solely technological investments—may have the most significant impact on improving the efficiency of organ utilization. Notably, the study highlights the importance of expanding the use of organs from expanded criteria donors (ECD), currently underutilized in Brazil. This research contributes to the literature by offering managerial insights and operational recommendations to increase the effectiveness of organ transplantation systems. While the findings are based on qualitative data and cannot be generalized, they provide valuable direction for future research and policy. Ultimately, improving the utilization of donated organs can significantly increase the number of transplants performed, contributing to better health outcomes and saving more lives.