This study aimed to measure and analyze the effect of compensation and supervision on job satisfaction through the discipline of regional contract labor at the Regional General Hospital of Central Mamuju Regency. This research design is a survey. It conducted this research at the Regional General Hospital of Central Mamuju Regency. This research lasted for about two months, from August to September 2019. Data collection was done through observation, questionnaires, interviews, and documentation. The total sample is 100 people—data analysis through research instrument test, validity test, reliability test, and path analysis. The results showed that the direct effect gave the highest correlation value among the variables studied compared to the indirect effect. The immediate impact of compensation on work discipline has the highest correlation value compared to the impact of other variables. Meanwhile, the lowest correlation is shown in the indirect effect of the supervision variable on job satisfaction through work discipline. The highest correlation found in this study, namely the direct impact of compensation on work discipline, shows that giving high balance and following expectations will create a good level of work discipline. Payment encourages a person to work more actively and actively and even exert all his ability to meet organizational expectations. This is what encourages health workers in the scope of the Central Mamuju Regency General Hospital to have high work discipline behavior because of the high expectation of the value of the compensation given. Meanwhile, the lowest correlation shows a mismatch in acting through supervision towards increasing satisfaction through work discipline. Management without joy will encourage a good level of discipline, so the influence of this relationship is not considerable but positive.