Lean Manufacturing is an approach for the systematic identification and elimination of waste associated with manufacturing systems and services through continuous improvement by the flow of the product or service to the customer and in the pursuit of organizational sustainability. This article presents a structural equation model that relates the 5s and good manufacturing practices as independent variables with the economic sustainability (dependent variable) of maquiladora companies in Ciudad Juarez. The model proposes three hypotheses validated using the partial least squares technique integrated into the WarpPLS 7.0 software with the information obtained from 119 responses to a questionnaire applied to the local maquiladora industry. Likewise, a sensitivity analysis was performed in which the importance of properly implementing the 5s and what happens when they are not implemented correctly is observed. The results show that the 5s is a facilitator of good manufacturing practices since, through them, a reduction in the different costs incurred by the maquiladora industry is obtained.