Attention to the importance of indoor air quality (IAQ) has increased in recent years. It is a topic that has grabbed the interest of scholars, researchers, and the public. Unfortunately, research shows that many indoor locations such as houses, nurseries, schools and offices have been suffering from unhealthy indoor air. Current literature shows that the most significant indoor air contaminants are CO2, CO, NO2, O3, TVOCs, and particular matter along with thermal conditions such as temperature and humidity. The presence of those contaminants affects human health negatively. While different methods to improve indoor air do exist today, yet there is no one best solution. Green Lean Six Sigma (GLSS) frameworks has been used successfully to tackle the problems related to environmental issues in different fields. Accordingly, this paper tries to address a core question of the possibility of applying GLSS approach to improve indoor air quality within various facilities.  The definition of GLSS and an overview of the developed GLSS frameworks and their applications will be presented through a review of the relevant articles available in the literature. The findings will highlight possible challenges and featured strong promising research opportunities regarding the use of GLSS approach to improve indoor air quality. The major finding is that there is a lack of implementation of GLSS in different fields and exploring new fields will most probably show positive feedback.