Companies engaged in any field need to realize the importance of having innovation to increase growth and productivity in all sectors. Innovative work behavior becomes an important factor for organizational performance and long-term survival of employees. Quantitative techniques are used in this study by involving 100 respondents in F&B manufacturing industries beverages focused in Indonesia. The analysis of this study is a Structural Equation Model (SEM) approach with the help of smart PLS. The results show that knowledge acquisition does not affect innovative work behavior; leader role expectations affect innovative work behavior; perceive organizational support affect innovative work behavior; job satisfaction affect innovative work behavior. In the mediation hypothesis, it is found that job satisfaction is able to mediate the relationship between knowledge acquisition and leader role expectations; job satisfaction is not able to mediate the relationship between perceived organizational support and innovative work behavior. Then, the environmental dynamism variable is not able to moderate the relationship between knowledge acquisition and perceived organizational support on innovative work behavior; environmental dynamism is able to moderate the relationship between leader role expectations and innovative work behavior.